The workshop on “Decode proteomics

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Metabolic Pathway Analysis

Our Metabolic Pathway Analysis service employs bioinformatics tools like KEGG, Reactome, and MetaCyc to map and analyze biochemical pathways, providing insights into gene-protein interactions, metabolic functions, and the identification of key regulatory nodes in cellular processes.

Comparative Genomics

Our Comparative Genomics service utilizes bioinformatics tools like MAUVE for multiple genome alignment, OrthoMCL for ortholog detection, and phylogenetic analysis with MEGA, enabling detailed comparisons across species to uncover evolutionary relationships and conserved genetic elements.

Epigenomic Studies

Our Epigenomic Studies service leverages bioinformatics techniques such as DNA methylation analysis with Bismark, chromatin accessibility mapping with ATAC-seq, and histone modification analysis using ChIP-seq, providing comprehensive insights into epigenetic regulation and its impact on gene expression.

Protein-Protein Interaction Analysis

Our Protein-Protein Interaction service utilizes advanced techniques such as yeast two-hybrid screening, co-immunoprecipitation, and mass spectrometry to map and analyze interaction networks, providing comprehensive insights into cellular signaling pathways and molecular complexes.

Protein-DNA Interaction Analysis

Our Protein-DNA Interaction service provides precise mapping of binding sites using advanced techniques such as ChIP-seq, ATAC-seq, and CUT&RUN, offering detailed insights into transcription factor binding and gene regulatory mechanisms.

Gene Expression Profiling

Our Gene Expression Profiling service provides comprehensive analysis of gene activity across different conditions, utilizing advanced RNA-seq and microarray technologies to deliver accurate insights into gene regulation and expression patterns.

Virtual screening & QSAR

We can perform virtual screening and QSAR analysis to identify potential targets and optimize lead compounds for drug discovery. Our in-house tools, combined with machine learning and WEGA, are utilized for QSAR analysis.

Protein Engineering and Mutagenesis

Our protein engineering pipeline evaluates the impact of mutations on structure and function, covering sequence library generation, molecular modeling, docking, MD simulations, and post-analysis.

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MD Simulations

We offer comprehensive MD simulations from basic to advanced levels, encompassing Classical MD, All-Atom MD, Coarse-Grained MD, Umbrella Sampling, QM/MM, and Molecular Docking combined with MD. Our expertise spans a wide range of software, including GROMACS, AMBER, NAMD, CHARMM, Desmond, and Martini. Explore our services by requesting a quote below.

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Molecular Modelling & Docking

We offer comprehensive molecular modeling and a wide range of docking services, including protein-ligand (rigid, flexible, induced fit, blind, and site-specific), covalent, protein-protein, protein-nucleic acid, macromolecule docking, virtual screening, pharmacophore, and consensus docking.

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AI/ML aided Drug Discovery

We provide consultation on applying machine learning and artificial intelligence approaches to discover novel compounds and repurpose existing ones, in combination with classical drug discovery methods.

Drug Discovery via Classical Tools

Our CADD service spans disease-related genomics, target identification and validation, lead discovery, optimization, and preclinical testing with in silico ADMET and pharmacokinetics, ensuring efficient drug development from genomics to clinical trials.

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Graphics and Data analysis using Python & R packages

This service encompasses comprehensive graphics creation and data analysis using Python and R, leveraging their extensive libraries and packages to deliver precise and insightful results.”

3D Rendering and Infographics

Our services also incorporate the use of Industry-standard tools such as BioRender, Canva, Adobe Illustrator, Inkscape, and CellDesigner to produce publication-quality figures, infographics, and diagrams with a high level of precision and professionalism.

Core Bioinformatics Illustrators and Visualisation tools

Our services utilise well-known academic and commercial illustration tools such as PyMOL, VMD, Chimera, Cytoscape, LigPlot, Circos, IGV, Discovery Studio, Glide, and others to create publication-quality images that depict molecular and structural interactions, as well as pathway and network diagrams.

Population Genomics and Precision Medicine

We analyze genetic variations within and between populations to uncover evolutionary histories, population structure, and adaptation signals. This service extends to precision medicine by linking genetic variations to phenotypic traits and disease susceptibilities, ultimately enabling the development of tailored medical interventions and advancing personalized healthcare strategies.

Clustering and Network Analysis

We apply state-of-the-art machine learning techniques, both supervised and unsupervised, along with sophisticated network and cluster analysis tools. Through metabolic network modeling, graph theory, and linear optimization, we interpret high-dimensional datasets to identify patterns, reveal relationships, and map the connectivity within biological systems, leading to a deeper understanding of functional modules and regulatory pathways.

Molecular Evolution Studies

Our service reconstructs ancestral sequences, identifies adaptive changes, and deciphers the molecular mechanisms driving evolutionary diversity, offering profound insights into the genetic basis of evolutionary change. By leveraging comparative genomics, phylogenetics, and population genetics, we analyze patterns of natural selection, genetic drift, and mutation rates.

Genome Assembly and Annotation

Utilizing cutting-edge sequencing technologies and bioinformatics tools, we assemble fragmented genomic data into comprehensive sequences and annotate them to identify coding regions, regulatory elements, and functional genes. This service provides a detailed genetic map that unravels the organism’s blueprint, aiding in comparative genomics, evolutionary studies, and functional genomics.

Multi-Omics Integration

This service includes comprehensive multi-omic integration solutions that combine genomics, transcriptomics, proteomics, and metabolomics to provide a holistic understanding of biological systems and diseases. This approach enables precise biomarker discovery, personalized medicine, and the development of innovative therapeutic strategies.

NGS Basics to Advanced Analysis

We provide comprehensive data analysis and interpretation services for a wide range of sequencing technologies. Our expertise spans bulk sequencing, single-cell RNA sequencing, single-cell ATAC sequencing, CRISPR-based sequencing, RNA sequencing, ATAC sequencing, ChIP sequencing, spatial transcriptomics, and whole genome/exome sequencing. Through these advanced methods, we deliver in-depth insights into gene expression patterns and genetic diversity, enabling a thorough understanding of complex biological data.

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The workshop on “Decode proteomics

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